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Immunomodulatory nanoparticles (IMPs) are highly negatively charged, 500 nm-diameter particles composed of the biodegradable biopolymer carboxylated poly(lactic-co-glycolic) acid (PLGA-COOH) (Sharma et al., 2020

This suggests that the effects of MG extend beyond binding to GSH and involve the inhibition of GSH resynthesis and enzymes that play key roles in its synthesis, thereby promoting ferroptosis

Timing & therapeutic window Ferroptotic cell death in acute cardiac injury occurs within a narrow time frame, making the timing of intervention critical

uralensis under the S condition and the increased fructose content in G

Moreover, another study by Sagrillo-Fagundes and his group found that melatonin significantly regulated autophagy and inflammation in primary trophoblast cells that were exposed to a hypoxic/reoxygenation environment, mimicking preeclamptic pregnancy, thus reducing apoptosis in these cells

doi: Emmez H, Yildirim Z, Kale A, Tnge M, Durda E, Brcek A, Uanku LN, Doulu F, Kili N, Baykaner MK (2010) Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemiareperfusion injury in rabbits