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In people who have a vitamin B12 deficiency, the body cannot make enough healthy red blood cells

Unlike NAD+ precursors that work downstream, 5-Amino-1MQ acts upstream by blocking NNMTs consumption of S-adenosyl methionine (SAM), resulting in elevated intracellular NAD+ and SAM levels without requiring direct nucleotide supplementation

Vitamin D supplementation may result in hypercalcemia in certain individuals taking digoxin or thiazide diuretics

folic acid may improve anemia but not prevent nerve damage

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The Food and Drug Administration approved the updated shots for adults and children as young as age 6 months