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doi: 10.1073/pnas.2332818100

MOTS-c is often provided as a lyophilized powder that must be reconstituted with bacteriostatic water using sterile technique before use

This contrasts with TB-500, which is explicitly WADA-prohibited under S2

Starting Concentration and Gradual Introduction Many dermatologists recommend starting with lower concentrations, under 0.5%, and gradually increasing to higher strengths as your skin acclimates