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It was also reported that lysine (K)-specific demethylase 4A (KDM4A), which was highly expressed in cervical cancer tissue and could be induced under cobalt chloride mimicking hypoxia conditions, reduces the H3K9me3 level in the HIF-1 promoter region to elevate HIF-1 transcription, leading to the increased expression of TFRC and DMT1 via activating the HRE sequence in their promoters, and finally resulting in the increase in erastin-induced ferroptosis of cervical cancer cells [120]

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