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PD as a metabolic iceberg PD may also be conceptualized as a metabolic iceberg, with the hallmark clinical, anatomical, and pathological features emerging as late-stage effects of impaired mitochondrial biology (Fig

Wang, D., Zhang, F

In various models, including experimental autoimmune encephalomyelitis (EAE), psoriasis, and arthritis, T17 cells have been identified as a critical early source of IL-17, often preceding the activation of Th17 cells (133)