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Inhibition of non-c-Met targets may enhance the antitumor activity of non-selective c-Met inhibitors, but is also correlated with increased toxicity and limits the dose so that inhibitors cannot effectively suppress c-Met (Bouattour et al., 2018)

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Effects on the Cardiovascular System Hydrocodone produces peripheral vasodilation which may result in orthostatic hypotension or syncope

Identify patients at risk for cardiac iron overload Magnetic resonance imaging Cardiac magnetic resonance imaging (CMRI), especially T2*CMRI, is an excellent non-invasive detection method for identifying iron deposits within the heart (95, 96)