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Usually a deficiency is caused by an increased demand for folate through pregnancy or hemolytic anemias such as Sickle Cell Disease

Han et al., 2015

Under reducing, non-stress conditions, four highly conserved cysteine residues, which constitute one of the stress sensor domains, are kept in their reduced thiol state and together coordinate one zinc(II) ion [287]

Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine Anal

When S is low, 1-1.4, the GS flux rises more rapidly than the GPX flux, pushing GSH up