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There's human evidence of that

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No delayed-onset adverse effects emerged that were not apparent in the initial weeks of treatment

Upon extravasation, neutrophils release cytotoxic compounds, including reactive oxygen species (ROS) and proteases, and can form neutrophil extracellular traps (NETs), contributing directly to parenchymal damage [13]

Mult Scler Perspect Treat Pathog 125138

Antiemetics like prochlorperazine or metoclopramide pull double duty, not only quieting nausea but also helping to reduce the migraine pain itself through their effects on dopamine receptors