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Although thioredoxin is not itself imported into the ER (being an 11.6 kDa protein rather than a small tripeptide like glutathione), the pathway has been shown to influence ER lumenal redox potential, likely through the conveyance of reducing equivalents through an as-yet unknown ER-resident transmembrane protein (Poet et al., 2017)

American Journal of Clinical Nutrition, 76(5), 1151S-1157S

For example, one can use a flow cytometry-based selection systems

Clomipramine: Serotonin syndrome was reported following concomitant administration of clomipramine and intramuscular S-adenosylmethionine (13)

Cell Biochem Biophys 2025;83:811-21