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Although serious allergic reactions to Bcomplex vitamins are rare, they can occur and may include symptoms such as rash, itching, hives, swelling of the face, lips, or throat, severe dizziness, or difficulty breathing

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On the other hand, canker sores (or aphthous ulcers) are noncontagious lesions that occur inside the oral cavity and are believed to be caused by various factors, including stress, inflammation, gut dysbiosis, nutritional deficiencies, and immune system dysregulation (figure 2)

583, 127-132, doi:10.1038/s41586-020-2403-9

True anaphylaxis to peptide therapeutics is documented for approved drugs including native GLP-1 receptor agonists and insulin analogs