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10.1073/pnas.1508220112 Proc

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Depending on the dosage, Epitalon was observed to either reduce the maximum lifespan of micedue to debilitation and the aggregation of frail individuals in the populationor significantly enhance survival rates in transgenic miceattributable to adaptability, increased average robustness, and heterogeneity [72]

Since no covalent bonds are needed, this delivery method may carry several molecules of an anticancer medication without appreciably altering the antibody's capacity to target tumors

In particular, carrier family 38 member 1 (SLC38A1)- and SLC1A5-mediated l-glutamine (but not d-glutamine) uptake and subsequent glutaminase 2 (GLS2, but not GLS1)-mediated glutamate production is required for cystine deprivation- or erastin-induced ferroptosis 40 (Fig