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Disclosures: Robert Wong: Theratechnologies: Grant/Research Support, Durect: Grant/Research Support, Gilead Sciences: Grant/Research Support, Exact Sciences: Grant/Research Support, Theratechnologies: Grant/Research Support, Durect Corporation: Grant/Research Support, Zeyuan Yang: Nothing to Disclose, Wei Zhang: Nothing to Disclose, Brian Lee: NIAAA: Grant/Research Support, Novo Nordisk: Advisor, GSK: Advisor, DURECT: Advisor, HepaTx: Advisor, CymaBay: Consultant, Ipsen: Consultant, Siemens Healthineers: Grant/Research Support, Ramsey Cheung: Nothing to Disclose 1470 DEVELOPMENT OF AN EHR-BASED ALGORITHM TO IDENTIFY RECOMPENSATION IN ALCOHOL-ASSOCIATED LIVER DISEASE Puru Rattan 1 David Kaplan 1 Marina Serper 2 Nadim Mahmud 3 , 1 University of Pennsylvania, 2 University of Pennsylvania Health System, 3 Hospital of the University of Pennsylvania Background: The development of decompensation, specifically ascites, hepatic encephalopathy, and/or variceal bleeding, represents a watershed point in cirrhosis and is the main indication for transplantation
Researchers found that metformin could regulate endometrial tolerance by increasing endometrial glucose transporter protein 4 (GLUT4) expression, modulating the expression of related hormone receptors to affect endometrial transformation, modifying autophagy, as well as modulating DNA/histone modifications and micro RNAs (miRNAs) for transcriptional regulation
A B12 deficiency can also lead to health problems that can lead to major birth defects
