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46 , 377382 (2011) E.A

Loss-of-function mutations in either TSC1 or TSC2 lead to constitutive mTORC1 activation, which contributes to uncontrolled growth and underlies the TSC disease (19)

It is associated with vascular abnormalities, skin and organ fibrosis, immune dysfunction, and excessive deposition of extracellular matrix, affecting multiple organs including the skin, lungs, stomach, and kidneys

TRIUMPH-4: Metabolic findings beyond weight TRIUMPH-4 also produced two metabolic findings that are relevant beyond weight loss itself

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The increase in IGF-1 also supports cellular repair, joint health, and improved metabolism