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doi: 10.4239/wjd.v6.i4.548 Summary Keywords adipose tissue dysfunction, metabolic disorders, insulin resistance, inflammatory pathways, adipokine dysregulation, oxidative stress, mitochondrial dysfunction, cellular senescence Citation Bou Matar D, Zhra M, Nassar WK, Altemyatt H, Naureen A, Abotouk N, Elahi MA and Aljada A (2025) Adipose tissue dysfunction disrupts metabolic homeostasis: mechanisms linking fat dysregulation to disease