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Kopetz S , Zagonel V, Overman MJ, McDermott R, Morse MA, Chen FL, Lee J, Moss RA, Ling L, Greenfield A, Greenawalt D, Cao ZA

28 However, naltrexone should be avoided in those with acute liver failure or decompensated cirrhosis

An important role of the pepper phenylalanine ammonia-lyase gene (PAL1) in salicylic acid-dependent signalling of the defence response to microbial pathogens

Doctors can also help find ways to make treatment more affordable

While the compound has shown efficacy in animal models, he notes that more research is needed to fully understand the risks and benefits for human use, especially over extended periods