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Four subjects (13%) on active treatment had a severe adverse event, most commonly pneumonia (Table 13)

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explored the relationship between gut microbiota and short-chain fatty acids in renal calcium oxalate stone disease and found that gut microbiota dysbiosis is associated with altered oxalate metabolism ( Probiotics or prebiotics may modulate the gut microbiota to enhance oxalate degradation

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The 500 mg dose can be doubled (2 tablets = 1,000 mg) to reach the clinical threshold