foxo4-dri senolytic mice baar 2017 Frontiers FOXO4-DRI: Kill Senescent Cells, Restore
FOXO4 DRI: Kill Senescent Cells, Restore Organs (2026) FOXO4 DRI FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells eBioMedicine Molecule kills elderly cells, reduces signs of aging in mice Science AAAS The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications
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