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Cell Transplant 2023;32:9636897231167213

doi:10.1056/NEJMoa1812792 Yokoyama M, Origasa H, Matsuzaki M, et al

Neuroinflammation is mediated by activated glial cells and infiltrating lymphocytes, accompanied by the production of pro-inflammatory cytokines and neurotoxic or neuroprotective molecules [160]

However, by reducing the acidity of the gastric lumen, these drugs also inhibit the bodys ability to absorb B12 by preventing its splitting from the carrier protein molecules