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LPS-induced miR-21-3p overexpression increased the protein and mRNA levels of the inflammatory cytokines monocyte chemoattractant protein-1 (MCP-1) and IL-6 in RPE cells while elevating apoptosis, caspase-3 activity, and levels of cleaved caspase-3 and poly-(ADP-ribose) polymerase proteins, which exacerbate inflammatory responses and apoptosis

GAPDH inhibition caused significant changes in PPP metabolite labeling

10.1186/1472-6882-6-10 127 LatimerB.EkshyyanO.NathanN.Moore-MedlinT.RongX.MaX.et al (2015)

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During SARS-CoV-2 infection, neutrophils are recruited to the lungs and release NE, which contributes to tissue damage and inflammation