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TB-500 also has anti-apoptotic effects (reducing cell death) and modulates immune cells to limit excessive inflammation and fibrosis

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50 The role of endoplasmic reticulum-associated degradation (ERAD) in the heart The ERAD pathway is a critical quality control mechanism that ensures the proper folding and degradation of misfolded or aberrant proteins within the ER 51 (Fig

The TEV protease itself, with various mutations used to increase its stability activity, can be readily purified using plasmids found in this paper (available at Addgene)

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