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Furthermore, although an alum-adjuvanted double-inactivated SARS-CoV vaccine elicited higher antibody titres in aged mice, it skewed the IgG subclass toward IgG1 instead of IgG2, which was associated with a T helper 2 (T H 2)-type immune response, enhanced eosinophilia and lung pathology 13

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Figure 2 Vagus nerve The vagus nerve is the main nerve of the parasympathetic branch (96), which can participate in taste sensation and innervate most organs, including the liver, stomach, and pancreas, and regulate circulation, breathing, and digestion by conducting sensory impulses in organs, particularly those controlling the activity of the heart muscle, glands, and smooth muscles (97, 98)