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(2022b) investigated associations between maternal serum aspartame (and sucralose) levels and metabolic health during pregnancy in a nested population-based casecontrol study

Pro-apoptotic and pro-inflammatory genes were significantly enriched with hypomethylated CpG sites in healthy AAs, with genetic variants within and directly disrupting CpG sites accounting for some ethnic-specific variability in DNA methylation.78 These ethnic-specific differences in methylation may help explain racial disparities in outcomes and disease manifestations observed in SLE