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the major mechanisms by which the drug is cleaved from the antibody include hydrolysis in the acidic pH of the lysosomes (hydrazones, acetals, and cis-aconitate-like amides), peptide cleavage by lysosomal enzymes (the cathepsins and other lysosomal enzymes), and reduction of disulfides

Proc Natl Acad Sci USA 98: 51165121 ValleCasuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, AvettandFenoel V, Boufassa F, Sitbon M et al (2019) Cellular metabolism is a major determinant of HIV1 reservoir seeding in CD4 T cells and offers an opportunity to tackle infection

Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase

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BresellA.WeinanderR.LundqvistG.RazaH.ShimojiM.SunT

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