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Through reduction in beneficial SCFAs, gut dysbiosis impares gut function and contributing to systemic inflammation and oxidative stress

These challenges include the lack of crystal structure of ChaC1, the absence of prior inhibitors, and most importantly the high Km of ChaC1 for glutathione

Unsaturated fatty acid moieties of membrane lipids are attacked by free radicals, which leads to a self-replicating chain reaction of non-enzymatic lipid peroxidation that produces malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), isoprostains and other compounds

Activation of antioxidant signaling pathways Glutathione is an important intracellular antioxidant that also plays a role in the detoxification and elimination of potential carcinogens and toxins

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