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The EMT-MET transition mechanisms are not commonly seen in childhood brain tumors, which limits their spread

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1.2 BRAF V600E -mutated CNS tumors striking inter-tumoral heterogeneity affects clinical prognosis BRAF V600E CNS tumors are enriched in the pediatric population and occur most frequently in pLGG (17-35% of pLGG) and are found in a diverse range of histopathologic subtypes of glioma

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Consistent with this, E2 suppresses hepatic lipogenesis and protects against metabolic dysfunction-associated steatosis liver disease (MASLD) [165], a condition characterised by hepatic lipid accumulation and linked to insulin resistance and type 2 diabetes [157, 166]