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However, ipilimumab monotherapy and combination therapy produce irAEs unlike those of traditional or newer targeted treatments and at higher rates and severity than with ICI monotherapy

The NOD2 gene has been repeatedly linked to PD susceptibility in studies that have linked it to Crohns disease (CD) closely (93)

Wang R, Li C, Cheng Z, Li M, Shi J, Zhang Z, et al

Delta-sleep-inducing peptide (DSIP) stimulates the release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro