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As a result, most if not all IgG4 MuSK antibodies are monovalent, rather than divalent, for their antigen (Koneczny et al., Figure 2 With the discovery of MuSK as the antigen, both in vitro and in vivo models provided strong evidence of the pathogenicity of MuSK antibodies

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The sham-operated group received an equal volume of vehicle solution in the same schedule

Each experiment was independently repeated at least three times