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Senzer N, Hanna N, Chung T, Hecht JR, Vogel S, Rosemurgy A, Javle M, Ried T, Chu K, Kessler P, Swisher S , Forastierre A, Posner M, Chang K, Nemunaitis J

No synthetic hormones, no conjugated equine estrogens

If you administer at 10 PM, peak activity hits at 24 AM when you're asleep and muscle protein synthesis is already suppressed by low amino acid availability

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The kidney toxicity mechanism, specifically the breakdown of D-amino acids by renal enzymes, would likely make extended continuous use problematic

This study investigates the incidence, clinical manifestations, and management of JHR in patients treated with penicillin G or ceftriaxone