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However, high concentrations of free fatty acids released by adipocytes paradoxically induce ferroptosis in myeloma cells (Panaroni 2022)

In particular, they found that, in the absence of BMAL1, NF-B-driven transcription was upregulated by the core circadian protein CLOCK, whereas BMAL1 hindered the CLOCK-induced increase in the activation of NF-B-regulated genes 71

doi: 10.1001/jama.2010.1361 225 AshizawaKImaizumiMUsaTTominagaTSeraNHidaAet al

Int J Biol Macromol 153:11761185

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Increases in serum ferritin and altered iron metabolism are known to occur with inflammation