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Importantly, the research group which developed GPNMB vaccines also reported that GPNMB is an important regulator of lysosomal activity, and that genetic depletion of GPNMB can lead to shortened replicative lifespan in vascular endothelial cells, vascular dysfunction and increased formation of atherosclerotic plaques, with its effect on other tissues and organs remaining unclear

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MGs are commonly referred to as smart or responsive materials because of their ability to endure bi-directional volumetric fluctuations in response to a diversity of external stimuli, such as alterations in temperature, ionic strength, or the presence of certain bio-molecules (Li X