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In the case of another compound, Semax, there was "insufficient evidence of effectiveness," the document states

[DOI] [PubMed] [Google Scholar] 4.Emanuel M.E., Gedde S.J

Do not use this product if you are pregnant or breastfeeding

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The leaky gut hypothesis is often linked to the formation of opioid peptides and their subsequent passage through the blood-brain barrier, with the idea that this process may be exacerbated by heightened intestinal permeability

Zahran WE, Emam MA (2018) Renoprotective effect of Spirulina platensis extract against nicotine-induced oxidative stress-mediated inflammation in rats