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Mechanistically, these effects appeared to be mediated through mitochondrial uncoupling, AMPK activation, modulation of mTOR and PPAR signaling, improved mitochondrial bioenergetics, antioxidant defense and global metabolic reprogramming (Fig

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Numerous clinical treatment drugs for HCC, including bevacizumab, sorafenib, lenvatinib, regorafenib, and cisplatin, increase ROS levels, activating the intrinsic apoptotic pathway [243,244,245,246,247]

Replace 100 l with sample or 100 l of a series of standards treated with 2-vinylpyridine, where appropriate, which are prepared as described in Step 2B