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B12 is a required cofactor for DNA synthesis without enough of it, cells can't replicate efficiently

Colony-forming unit-erythroid (CFU-E) cells are the most responsive to erythropoietin because they have the highest concentration of erythropoietin receptors (233, 238)

Nutrients 2022;14:2846

Fitzgerald 2022)

Arrest of cell cycle entry by FZR-1 and LIN-35 Rb To examine cooperation between fzr-1 and lin-35 in cell cycle arrest, we tested how inactivation of these genes affects expression of mcm-4 S phase reporter constructs