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Crohn's disease, irritable bowel syndrome) in inflamed intestinal mucosa, little or no DAO can be produced and thus histamine cannot be broken down sufficiently

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-Glutamyl-dipeptides: Easy Tools to Rapidly Probe the Stereoelectronic Properties of the Ionotropic Glutamate Receptor Binding Pocket

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In a general sense, we can prevent this by keeping glucose levels low and boosting glyoxalase