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Figure 1 The lipid mediator prostaglandin (PG)E 2 is a key player in inflammation, pain, fever, and cancer but is also known to regulate physiological functions in the gastrointestinal tract, in the kidney, and in the immune and nervous system (Sugimoto and Narumiya, 2007)

10.1016/0021-9150(71)90026-8 91 HarrisD

Kim SJ, Miller B, Kumagai H, Silverstein AR, Flores M, Yen K

The role and effects of eosinophils in various diseases have been explored

Drug Resist Updat 5:234248 Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C (2003) PI3K/Akt and apoptosis: size matters

However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)