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ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking

An open-label extension study of this trial showed maintained efficacy at stable dosing over 9 months [23]

The ImageJ Cell Counter software ( was used to manually count the number of cells in the areas of interest

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G4251) in 150 mM NaCl, 10 mM Tris pH 7.4, 1 mM EDTA, 10 mM -mercaptoethanol and 1 mM PMSF]

The thiol side chain of cysteine often participates in enzymatic reactions such as a nuecleophile (a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction)