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Lin P, Cao M, Xia F, Liao H, Sun H, Wang Q, et al

Mechanistically, the CD73/A2AR signaling cascade coordinates the de novo synthesis and consumption of GSH with GSSG accumulation and concomitant mitochondrial lipid peroxidation, which links potentially to PKA/E2F1dependent fine-tuning of the ratio of GSR to GPX4

Nitrative stress is directly related to oxidative stress

It inhibits melanin synthesis, neutralizes free radicals and improves cell renewal

However, when their concentrations exceed the normal range, oxidative stress can disrupt the balance between oxidation and antioxidant defense systems

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