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576 Tetrahydroxy stilbene glycoside (TSG) enhances the activation of Keap1/Nrf2/ARE and GSH/GPX4 signaling pathways, reduces ferroptosis by regulating the levels of ferroptosis-related proteins and enzymes, and thus inhibits the production and deposition of A in the brain of APP/PS1 mice, 577 suggesting that TSG may be a promising therapeutic agent for AD by targeting ferroptosis

Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system

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For instance, animal models for SZ that show both high oxidative stress levels and PFC hypomyelination (such as the APO-SUS rats, and the rodent prenatal infection and hypoxia models) may be treated with antioxidants from a young age onwards to assess whether lowering oxidative stress can (partially) rescue myelination deficits in the PFC, together with PFC-dependent cognitive functioning, and evaluate the width of the therapeutic window

1, Koschmieder et al

Abstract Genetic diversity in the apolipoprotein E (ApoE) gene has been identified as the major susceptibility genetic risk factor for sporadic Alzheimers disease (SAD)