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Notably, our study appears to reveal a contradiction between the decreased TGF- production in ECs and the observed EndMT, as TGF- is a major inducer of EndMT

it is closely related to mitochondrial quality control in various cells and is often accompanied by apoptosis, pyroptosis, and ferroptosis of macrophages as well as endothelial cells [221]

Nitric oxide synthase 2 induction promotes right ventricular fibrosis

Similar to humans, altered dermal redox homeostasis in dogs has been linked to certain skin diseases, particularly atopic dermatitis [198,199,200,201,202]

PAD4 catalyzes the citrullination/deimination of arginine residues of proteins, leading to the citrullination of histones, which is speculated to be critical for the formation of NETs