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Retinal pigmented epithelial (RPE) cell malfunction and subsequent photoreceptor degeneration can lead to vision loss, exemplified by conditions such as age-related macular degeneration (AMD) 1

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The Uox KO/huXDH dual-model further achieves a powerful combination of a "hyperuricemia pathological background + human-specific target"

Seiler, M, Peng, S, Agrawal, AA, Palacino, J, Teng, T, Zhu, P, Liu, Y, Zhang, W, Akbani, R, Broom, BM, Ju, Z, Kanchi, RS, Korkut, A, Li, J, Liang, H, Ling, S, Liu, W, Lu, Y, Mills, GB, Uppore Kukkillaya, AR, Weinstein, JN, Zhang, J, Liu, X, Wang, L , Carvalho, AL, Fregnani, JG, Reis, RV, Scapulatempo, CN, Ajani, JA, Behrens, MC, Bondaruk, J, Broaddus, R, Czerniak, BA, Esmaeli, B, Fujimoto, J, Gershenwald, JE, Guo, CC, Lazar, A, Logothetis, CJ, Meric-Bernstam, F, Moran, C, Ramondetta, LM, Rice, DC, Sood, AK, Tamboli, P, Thompson, T, Troncoso, P, Tsao, A, Wistuba, II, von Deimling, A

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