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[] Another 8-week trial involving 52 benign prostatic hyperplasia (BPH) patients demonstrated that combined supplementation of lycopene and FruHis resulted in a more significant reduction in insulin-like growth factor 1 (IGF-1), total prostate-specific antigen (TPSA), symptom score, body mass index (BMI), and waist circumference (WC) compared with either supplement alone, with a notable effect observed specifically for IGF-1

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There are several examples of such facially selective addition of thiols to substituted sp 2 carbon atoms, including intramolecular conjugate addition in steroidal systems [38,39] and intermolecular addition directed by substrate stereochemistry [40,41] or a chiral auxiliary [42,43]

doi: 10.1136/postgradmedj-2017-135424 7

doi: 10.3390/v15071545 79 StylianouEAukrustPBendtzenKMllerFFrlandSS

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