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FACT 3 OF 6 IM injections for severe deficiency or absorption failure If your sublingual dose doesnt maintain serum B12 above 400 pg/mL, switch to intramuscular injections: 1,000 mcg monthly (more often initially if very deficient)

That gap in guidance is why so many people dread their weekly tirzepatide dose when, in reality, thigh injections can be the most comfortable option available

Muscle is vital for health

Direct injection can damage peptide structure through mechanical stress

Reconstitute: Add 3.0 mL bacteriostatic water 3.33 mg/mL total concentration (1.67 mg/mL of each peptide)

Wang J, Obici S, Morgan K, Barzilai N, Feng Z, Rossetti L