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Therefore, rational combination approaches that concurrently target MDSCs and the complex immunosuppressive network in the TME, together with biomarker-guided patient selection to enable personalized therapies, are critical for clinical success (7)

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33 Exosomes are a class of small extracellular vesicles (30100 nm) released by most cells

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IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

J., & Sarkar, B