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Interestingly, the structure of enzymatically oxidized PDA differs from that of traditionally oxidized PDA

The N-terminus mainly maintains the helical structure of -syn, and familial PD-associated mutations in the SNCA gene frequently occur in this region

In contrast, the distances between the two domains were not shortened during mitosis relative to interphase in cells depleted of Cnd1 or expressing Cnd1-K658E (Supplementary Fig