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Most significant effect on tumor responses was achieved by immunotherapy or targeted therapy using small-molecule drugs and monoclonal antibodies so far

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Curr Genomics , 2013, 14(2): 147-156

A novel ferroptosis-related 12-gene signature predicts clinical prognosis and reveals immune relevancy in clear cell renal cell carcinoma

A number of underlying mechanisms have been proposed, including increased oxidative stress, disruption of normal hormonal and neurological signaling, impaired cellular and mitochondrial processes, formation of abnormal proteins, and DNA damage