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But the jump from C57BL/6 mice to humans involves differences in metabolic rate, NNMT tissue distribution, adipose tissue physiology, and drug metabolism that preclinical data cannot address

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Meanwhile, overall aging indicators were significantly improved: locomotor activity and endurance were enhanced, hair gloss increased, levels of aging-related inflammatory factors (such as TNF-, IL-6) decreased, and the average lifespan of mice was prolonged

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Studies demonstrate that NNMT inhibition "enhances fasting blood glucose levels, glucose tolerance, and insulin sensitivity" while reducing triglycerides and decreasing lipid deposition