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A recent study on clear cell renal cell carcinoma showed that the iron sulfur cluster assembly 2 (ISCA2), a component of the late mitochondrial iron sulfur cluster assembly complex, was induced by hypoxia (1% O 2 ) to promote HIF-1/HIF-2 translation, leading to the inhibition of iron overload and erastin- or RSL3-induced ferroptosis [102]

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