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Sixty female SpragueDawley rats were randomly assigned to six groups: control (sham exposure), autophagy inhibition (3-methyladenine, 3-MA), autophagy activation (rapamycin, RAP), +Gz exposure, +Gz exposure with autophagy inhibition, and +Gz exposure with autophagy activation

That is, their study finally demonstrated that AS-IV may exert an anticardiac fibrotic benefit by downregulating oxidative stress-mediated MAPK phosphorylation through the targeted inhibition of ISO-induced ROS production

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