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Finally, the indiscriminate use of Se supplements should be taken with caution given its possible toxic effects that occur when exceeding its recommended consumption limits

[171] reported that APOE*3Leiden.CETP mice exposed to alternating lightdark cycleinduced circadian disruption presented a notable increase in atherosclerosis, with a nearly twofold increase in the size and severity of lesions [171]

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Soc, 2009, 131, 63626363