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Model group : Rats were subcutaneously injected with (2 mg/kg/day) rotenone for four weeks and continued without treatment [47]

Effect of water stress on the chloroplast antioxidant system

Although these study designs provide evidence of efficacy for the newer drugs, because the comparison is between active drug and placebo in patients who continue to have seizures in spite of current treatment with standard AEDs, it is difficult to compare the efficacy of the newer drugs directly with the older AEDs